This isn't a solution, but it will likely help: avoid using '*' to specify the columns you want and specify them explicitly. When you use * to specify all columns, MySQL has to do more work shunting data around when it's sorting the data, thus more likely to do a filesort, which is slow.
The only other way I can think off to get around this would be to alter the table to default the order by - and then remove the order by from your query all together.
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