Cancers are often viewed as systems diseases (Hornberg et.al, Biosystems 2006), because their occurrence is often strongly connected to large-scale modifications of signaling pathways, especially their cross-talks (Stelling et.al, Cell 2004). Accordingly, detecting which proteins (or cross-talks) are differentially expressed (utilized) in a carcinoma tissue may point out key causes of the given type of cancer and can help to identify novel systems-based drug targets (Tortora et.al, J. Chemoter 2004, Korcsmaros et.al, Exp.
Op. Drug Discov. 2007).
In Korcsmaros et. Al. (2009) we merged the network of 8 human signaling pathways with protein expression data from two human liver carcinomas.
We considered a signaling interaction to be altered in these two liver carcinomas, if, compared to healthy liver tissues, at least one of the participating proteins was differentially expressed. For details see Methods and the Supplementary Material of the paper. More.
I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.