There are four patients who have been on endostatin for 3.5 years or more with metastases of the liver. The tumors have stopped growing or arrested, mainly arrested. The patients love the drug.
They don't lose their hair, they maintain normal weight, they're not nauseated, they go back to work, and they have strength." But the clinical studies of endostatin stopped in February 2005, and supplies ran out a few months later. "After August 2, 2005, there was no more endostatin in the United States," said Folkman, whose laboratory discovered the molecule about a decade ago.
Endostatin is a protein produced by a fragment of the human gene collagen XVIII. Research by Folkman and others showed it could be a potent inhibitor of angiogenesis, a process that triggers blood vessel formation in so they grow larger. Following a New York Times feature, the drug was rapidly pushed to clinical trials.
By traditional measures, early trials of endostatin failed. But angiogenesis inhibitors don' ... more.
I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.