It sounds very much like your NewMessageNotification: method is not being called on the main thread; UI updates must only be done from the main thread, or things won't work correctly.
It sounds like you probably have two different instances of your class, one of which is hooked up to all the stuff in the nib and one of which is registering for the notification. Try logging self in that method and you'll probably see different object addresses when it's triggered by the notification versus the button.
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