Can CSNB be traced to one particular Appaloosa horse, bloodline, coat pattern or pigment definition?

The 2005-06 study proved that only one variable was significantly associated with the presence of CSNB in the Appaloosa: homozygous coat pattern. The determining factor was the horse’s status with respect to LP. Those with two dominant copies were CSNB-affected, while horses with only one, or no copies, were not.

No evidence for bloodline-specific inheritance was found. The horses in the study were selected because they were unrelated. Pedigree analysis revealed no significant common ancestry.

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