Can I take antidepressant medication if I am pregnant?

Ask your prenatal care provider to recommend a psychiatrist, clinical nurse specialist, or other medical provider who is experienced with prescribing medication. The potential benefits and harms of antidepressant medicines during pregnancy should be considered on an individual basis, taking into account the severity of your depression. Many medicines for depression belong to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs).

SSRI medications include Prozac, Zoloft, Paxil, Lenox, Celexa, and Lexapro. Wellbutrin, Remeron, and Effexor are also widely prescribed; while these drugs are not SSRIs, they act on the brain in similar ways. All of these drugs are considered "second-generation" antidepressants because they have largely replaced the older tricyclic antidepressants.

These psychotropic medicines affect the central nervous system and may restore emotions or moods to normal. While antidepressant medications are widely believed to be effective and are clearly helpful for some people, there is some controversy over how effective and how safe they are. One large review of research studies found that these drugs are only slightly more effective than placebos.

The 2006 FDA review looked at 372 placebo-controlled antidepressant trials that included nearly a hundred thousand people. It found that four out of ten people who received a placebo improved, while five out of ten people who received an antidepressant improved. This means that only one additional person out of ten responded to treatment with antidepressants.

Pregnant women, who are struggling with other problems, such as bipolar disorder (commonly called "manic depression" and anxiety, may be offered other medicines in addition to or instead of the second-generation antidepressants. If a doctor suggests any medicine, make sure that you are fully informed about all the possible benefits and adverse effects of the medicine.

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