Can I use Omnisphere in multimedia/game music projects?

Yes, this is OK unless you want to put samples created with Spectrasonics Virtual Instruments directly encoded into the game. That requires a special license. Remember, music use is allowed, but non-music use (example: SFX) is not permitted without a special license for this type of use.

Please contact Spectrasonics if you wish to encode the samples into a game system. More.

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