Does Campylobacter jejuni infection elicit "demyelinating" Guillain-Barre syndrome?

GROUND: Campylobacter jejuni enteritis is the most common antecedent infection in Guillain-Barré syndrome (GBS). C. Jejuni-related GBS is usually acute motor axonal neuropathy (AMAN), but previous reports described many cases of the demyelinating subtype of GBS (acute inflammatory demyelinating polyneuropathy AIDP) after C.

Jejuni infection. OBJECTIVE: To investigate whether C. Jejuni infection elicits AIDP.

METHODS: In 159 consecutive patients with GBS, antibodies against C. Jejuni were measured using ELISA. Antecedent C.

Jejuni infection was determined by the strict criteria of positive C. Jejuni serology and a history of a diarrheal illness within the previous 3 weeks. Electrodiagnostic studies were performed weekly for the first 4 weeks, and sequential findings were analyzed.

RESULTS: There was evidence of recent C. Jejuni infection in 22 (14%) patients. By electrodiagnostic criteria, these patients were classified with AMAN (n = 16; 73%) or AIDP (n = 5; 23%) or as unclassified ... more.

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