Does eradication of Helicobacter pylori alone heal duodenal ulcers?

GROUND: Eradication of Helicobacter pylori infection prevents duodenal ulcer (DU) relapse, but it remains uncertain whether eradication of H. Pylori alone heals duodenal ulceration. AIM: To test the hypothesis that eradication of H.

Pylori infection is accompanied by healing of duodenal ulcer. METHODS: A total of 115 consecutive patients with endoscopically confirmed H. Pylori-infected duodenal ulcer were randomly assigned to one of two groups.

Group BTC patients received a 1-week course of colloidal bismuth subcitrate 220 mg b.d. , tinidazole 500 mg b.d. , clarithromycin 250 mg b.d.

Group OBTC patients received omeprazole 20 mg daily for 4 weeks with the BTC regimen during the first week. Endoscopy with antral biopsies and 13C-urea breath test (UBT) were performed before and 4 weeks after completion of the 7-day triple or quadruple therapy. RESULTS: Eight patients dropped out (four in BTC and four in OBTC).

Duodenal ulcer healing rates on an intention-to-treat basis in BTC and OBTC ... more.

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