Does pravastatin therapy affect cardiac enzyme levels after percutaneous coronary intervention?

Author(s): Bozbas H, Yildirir A, Mermer S, Konas D, Atar I, Aydinalp A, Ozin B, Korkmaz ME, Muderrisoglu H Affiliation(s): Department of Cardiology, Faculty of Medicine, Baskent University, Ankara, Turkey. [email protected] Publication date & source: 2007-05, Adv Ther. , 24(3):493-504.

Publication type: Randomized Controlled Trial Serum cardiac enzyme elevation after percutaneous coronary intervention (PCI), a relatively common complication, is a prognostic determinant of long-term outcome in patients who undergo these procedures. Statins are postulated to reduce such complications. This study investigated the short-term effects of pravastatin on serum creatine kinase myocardial isoform (CK-MB) and serum cardiac troponin I (cTpI) levels after elective PCI.

Of 93 patients studied, 72 (77.4%) were men, and 21 (22.6%) were women (mean age, 58.9+/-11.0 y). Patients were randomly divided into 3 groups before they underwent elective PCI. Preoperatively, group 1 patients (n=30) received ... more.

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