Handling large amounts of file uploads - Any limitations I should know of?

Really depends on what filesystem your server is using, for instance, ntfs can hold as many as 4,294,967,295 in a single folder, whereas FAT32 can hold as many as 65,534 files in a single folder.

There are quite many issues that couldappear, from file system limitations to backup problems. I suggest using the first X characters of tue UUIS as folder name - possibly multiple levels deep (first 4, second 43, third 4). This way you have one structure but can back up folders and move them to different servers if needed later (by using the folders as redirection points).

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