Have you heard of intravenous cytoxan treatment for Transverse Myelitis associated with lupus?

Systemic lupus erythematosis (SLE) is a chronic autoimmune disease that affects many organs and may vary greatly in severity and which organs are affected from person to person. Some people with SLE have rashes, arthritis, mouth ulcers, or problems with kidneys, lungs, or blood cells. Involvement of the central nervous system (brain and spinal cord) is also common in SLE.

Transverse Myelitis may occur in SLE and often this may be severe, recurrent or progressive. Because of this, aggressive immunosuppression is recommended by some researchers. Prednisone is the traditional treatment for the various problems associated with SLE.

However, chronic prednisone use is often associated with significant side effects, such as osteoporosis and catarracts. In addition, at times the myelitis associated with SLE may be so aggressive that it does not respond to prednisone alone. One regimen that has been recommended is the use of corticosteroids in combination with cyclophosphamide.

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