How common is it for a woman to have identical quadruplets?

Dr. Abbasi: This is a really rare event. Spontaneous identical quadruplets occur in about 1 in 13 million pregnancies. By contrast, 1 in 100 pregnancies produce twins.

What causes a woman to have identical quads? Dr. Abbasi: What happens with identical twins is that just before the embryo implants, it splits into two. And because embryo cells (at this stage of development) are “totipotent” i.e.

Able to form an entire organism each one can replicate itself into a completely new embryo, which eventually becomes an identical twin. Identical quadruplets result from the embryo splitting 4 times by chance – which is extremely unlikely to happen in one embryo. While we know the cause of the twinning (the division of the embryo at a very early stage) we don’t know the trigger behind the spontaneous splitting.

When we do embryo (blastocyst) transfers with in vitro fertilization (IVF) we may implant 2 embryos and get 3 babies because one of those embryos splits. Do certain women have a ... more.

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