How does 5-HT1AR deficiency lead to altered hippocampal oscillations?

From the limited literature on serotonergic effects on ripple oscillations, it seems likely that a decrease in ripple amplitude cannot be explained by a simple lack of the receptor in the adult. It is difficult to reconcile decreased ripple size, which suggests less excitation of CA1 pyramidal neurons (Csicsvari et al. , 1999), with the absence of an inhibitory receptor.

A recent report showed that pharmacological blockade of the 5-HT1AR with the specific antagonist WAY 100635 (N-2-4-(2-methoxyphenyl)-1-piperazinyl ethyl-N-(2-pyridinyl)cyclo-hexane carboxamide trihydrochloride) resulted in less frequent but normal-sized ripples (Ponomarenko et al. , 2003) as opposed to the smaller but equally frequent ripples seen here in the knock-outs. These data argue that the change in ripple size seen in the knock-outs is likely attributable to an indirect effect of 5-HT1AR deletion, perhaps as a consequence of altered hippocampal development.

Alternatively, serotonergic drugs are known to ... more.

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