How does exercise reduce the risk of prostate cancer?

Very high levels of physical activity, at least in older men, may reduce the risk of prostate cancer. Preliminary observations in the College Study suggest that men who expended 4,000 or more calories a week in physical activity may have a lower risk of prostate cancer compared with men who expended fewer than 1,000 calories a week. We know there's a link between high levels of the male hormone testosterone and an increased risk of prostate cancer.

Likewise, we know that especially heavy exercise decreases testosterone, suggesting a link between high levels of exercise and a reduced risk of prostate cancer. Obesity and high-fat diets are also associated with an increased risk of prostate cancer, and again, because men who exercise regularly tend to cut their intake of dietary fats, and because they tend to be leaner than average, it makes sense that physical activity might be associated with a reduced risk, although it may not be a cause-and-effect relation.

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