How does HPV cause cervical cancer?

Genital human papillomavirus (HPV) — a sexually transmitted infection — is the most common cause of cervical cancer. When a woman is exposed to HPV, her immune system usually prevents the virus from doing any serious harm. But in a small number of women, the virus survives for years.

Eventually, the virus can lead to the conversion of normal cells on the surface of the cervix into cancerous cells. At first, the cells may only show signs of a viral infection. Eventually, however, the cells may develop precancerous changes.

This is known as cervical intraepithelial neoplasia. Typically, the precancerous changes clear spontaneously. In some cases, however — particularly for people who have weak immune systems — cervical intraepithelial neoplasia eventually progresses to invasive cervical cancer.

It's not clear why some women are more likely to develop cervical cancer. Some types of HPV are simply more aggressive than are others. Cigarette smoking also increases the risk of cervical ... more.

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