How is rejection prevented and controlled when the patient's own immune system is still functioning in a mini (non-myeloablative) stem-cell transplant?

First, cells from a fully HLA-matched donor are used whenever possible to reduce the risk of rejection. Low-dose radiation, with or without chemotherapy, is used before the transplant to suppress, rather than destroy the patient's immune system. Immunosuppressant drugs are then used to maintain the immune suppression at the proper level.

Carefully controlling the level of immunosuppression allows the donor stem cells to take hold and begin producing a full range of blood and immune system cells in the patient. For more information, go to: • http://www.asheducationbook.org/cgi/content/full/2002/1/392 • hep.uchicago.edu/~seturner/minivsfull. More.

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