How is systemic medication helpful for treating acne?

Acne patients take antibiotics and a vitamin A derivative orally, as wellas applying them topically, so they work from the inside out too. Antibiotics are used for inflammatory acne and isotretinoin (a vitamin A analog known by the brand name Accutane) for both comedonal and inflammatory forms. Antibiotics like tetracycline are prescribed in an eight-week course, usually in conjunction with a topical retinoid and a benzoyl peroxide antibiotic cleanser.

These days doctors are gravitating more to a new generation of low-dose antibiotics that have fewer side effects and will hopefully prevent antibiotic resistance. (Higher-dose antibiotics have been known to cause gastrointestinal problems and yeast infections.) These medications, such as Doryx, Solodyn, and Oracea, are not as harsh and have a similar, positive anti-inflammatory effect - but they have little if no antibacterial strength. Another excellent medicine is spironolactone.

Originally a diuretic, its anti-testosterone effects diminish acne - especially the persistent acne around the mouth.

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