How long is the usual course of oral isotretinoin for acne?

The effect of oral isotretinoin, especially in severe nodulocystic acne, can be dramatic. Most cases of severe acne respond to a single 4- to 6-month treatment course. In general, pustules heal more quickly than papules or nodules.

Also, lesions on the face, upper arms, and legs tend to respond more quickly than lesions on the back or chest. In some cases, treatment is started at a low dose in order to help the skin get acclimated to the drug before increasing to a higher dose in the months that follow.

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