How to run exe stored on machine A from machine B using VB6?

I'd check out PS Exec from Sysinternals. It does exactly what you want and does not require any VB6 goo, such as DCOM.

Getting the exe to run on machine B would be easy. Presumably you want it to run on machine A. I've never tried it myself, but this sounds like a job for DCOM.

Here's a Microsoft article that walks you through DCOM with VB6. You create an ActiveX exe on machine A, and then VB6 code running on machine B can call into the exe running on machine A. You haven't said what the exe actually needs to do, but presumably you can create one or more methods in a class to do it - whatever it is - and you can pass any necessary information between the machines with the method calls.

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