If you'd said "Christmas" I'd have said "Goose". The whole point of serving turkey, besides the historic aspect, is that it's a large piece of tasty meat that is pretty inexpensive, even when it's not on sale. This is also true of ham, which is why it's often served at Christmas (I've not seen it served at Thanksgiving as an alternative).
So I'd go with venison. It's more native than ham; not as rare or hard to find as buffalo (and thus as expensive). And it's likely I can find someone on the guest list with a hunter's license to provide it.
Duck or giant lobsters were also early choices, but they're a lot less practical for a crowd. But I draw the line at this.
A simply delicious pot roast or roast beef. The roast beef is especially flexible because you can still have mashed potatoes and whatnot. Chicken is also another possibility because you can keep the stuffing concept and pretty much everything else is the same.
All depends on what you like to eat, I guess. Thank goodness there isn't a "What you can serve for Thanksgiving" law. I would say be creative and serve something you wouldn't normally see.
That way you can make the holiday especially memorable!
I am a Latino so "Pernil" aka pork shoulder, is a staple at every Thanksgiving and probably the first choice over turkey in mi casa.
Prime rib, of course. With all the step families and in-laws, everyone is fairly scattered for Thanksgiving. Serving prime rib is a sure-fire way to make sure they show up at my house.
Best of all, the leftovers (if there are any) disappear quickly.
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