Not at all. LastWriteTime is updated after writing, not while writing. You need to rely on whatever program is doing the uploading to put a lock on the file.
Any decent one does. So that trying to open the file with, say, the FileStream constructor with FileShare. Read or FileShare.
None will throw an IOException. This will almost always work.
I'm not entirely sure how accurate your method would be. However, an alternative solution would be to attempt to open the file in exclusive mode (FileShare. None) within a try-catch, e.g.
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