Is harmful to the human liver. 3.8: Can creatine cause cancer?

Creatine could increase the risk of cancer, but very unlikely. Creatine and creatinine are precursors to some known mutagens, especially in the presence of certain pathogenic bacteria (such as E. Coli).

In healthy individuals, the bacteria capable of doing this are present only in very low numbers. They may also possibly be kept in check with probiotic supplementation. Also, many antioxidants have been found to reduce the carcinogenic effect of the compounds that may be produced.

Although a theoretical mechanism exists, creatine has not been linked with increased cancer risk. In fact, in some animal studies, it inhibited tumor growth. Coupled with the other health benefits of creatine, it is unlikely that this constitutes a significant concern, although it may with lifelong supplementation.

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