Side effects that have been associated with the use of Lupron Depot frequently include hot flashes and night sweats, and less frequently palpitations, syncope, and tachycardias. Other side effects include generalized pain, headaches, vaginitis, nausea/vomiting, fluid retention, weight gain, acne, hirsutism, joint pain, loss of sexual desire, depression, dizziness, nervousness, and breast changes such as tenderness and pain. There have been no deaths directly related to therapy with Lupron Depot.
Although Lupron is not a cure for endometriosis, the pain relief it provides can last for several years. During clinical trials, 63% percent of women diagnosed with mild endometriosis said they were symptom-free five years after the end of treatment. Only 26% percent of women diagnosed with severe endometriosis still reported that they were symptom-free after five years.
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