If you need to worry about losing 25, 35, even 50 pounds, your problem is not likely to be genetic. Only when your excess weight exceeds 100 pounds would most doctors consider testing for genetic abnormalities.) Researchers argue that obesity is more genetically linked than any other trait except height—and at least 50 percent of obesity cases clearly have genetic components. This may help explain the 95-percent failure rate after two years of those people who lose 50 pounds or more: They had plenty of willpower to lose (it's the argument that lean people tend to make is that lifestyle choices and lack of willpower are responsible for obesity) but regained the weight nonetheless.
My take: The waist-control game requires two players—environment and genetics. While 10 percent of the obese population has genetic challenges that may make a super-model contract impossible, the bigger risk with these genes is not in the weight itself, but the predispositions for risks associated with obesity. Even if your genes have made you pre-destined for a life of taking up two seats, that doesn't mean you should abdicate control over your body.
When you make the right behavioral and biological changes, you'll be able to stay healthy and avoid the bad side effects of obesity, like diabetes, high blood pressure, and arterial inflammation.
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