Blood of the hepatic portal vein contain de-oxygenated blood. All of the blood which pass through the intestine and spleen is delivered to the liver by the hepatic portal artery for detoxification. The liver also receives arterial blood, carrying oxygen, from the hepatic artery.
Blood flow to the liver is inimitable in that it receive both oxygenated and deoxygenated blood. As a result, portal blood has lower pO2 and perfusion pressure than the other organs of the body. Blood pass from branches of the portal vein through cavity between "plates" of hepatocytes called sinusoids.
Blood also flows from branches of the hepatic artery and mixes into the sinusoids to supply the hepatocytes next to oxygen. This mixture percolates through the sinusoids and collects surrounded by a central artery which drains into the hepatic vein. The hepatic capillary subsequently drains into the inferior vena cava.
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