Is the .NET Client Profile worth targetting?

Ultimately, it will not hurt any users if you target the Client Profile. This is because the client profile is a subset of the .net framework v3.5 sp1, and if v3.5 sp1 is already installed you don't need to install anything.

You can convert your managed applications to pure machine code using tools such as http://www.xenocode.com/ or http://www.remotesoft.com/linker/ so you won't need any . NET framework on the client machines at all.

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