Most database engines calculate their query plan based on statistics about the tables - for instance, if a table has a small number of rows, it's quicker to go to the table than the index. Those statistics are maintained during "normal" operation - e.g. Inserts, updates and deletes - but can get out of sync when table definitions are changed, or when you do bulk inserts.
MySQL has an EXPLAIN feature which will help you to understand the query.
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