There are numerous possible causes of muscle twitching. They include: Diet deficiency Drug overdose (caffeine) Drug side effect (such as from diuretics, corticosteroids, or estrogens) Exercise Twitches not caused by disease or disorders (benign twitches) Often affecting the eyelids, calf, or thumb Normal and quite common, often triggered by stress or anxiety Come and go, and do not last for more than a few days Nervous system conditions that can cause muscle twitching: Amyotrophic lateral sclerosis (ALS - Lou Gehrig's disease) Damage to the nerve that leads to a muscle Muscular dystrophy Spinal muscular atrophy Weak muscles (myopathy) Symptoms that suggest a nervous system disorder include: Loss of, or change in sensation Loss of muscle size (wasting) Weakness.
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