Review article: gastrointestinal bleeding with low-dose aspirin - what's the risk?

Author(s): Laine L Affiliation(s): Department of Medicine, U.S.C. School of Medicine, Los Angeles, CA 90033, USA. [email protected] Publication date & source: 2006-09-15, Aliment Pharmacol Ther. , 24(6):897-908.

Publication type: This review examines ulcers and gastrointestinal bleeding with low-dose aspirin, focusing on randomized placebo-controlled trials. The single endoscopic trial assessing ulcers showed no significant difference in 12-week ulcer incidence: 6% of 381 given placebo vs. 7% of 387 given 81 mg enteric-coated aspirin. The relative risk of major gastrointestinal bleeding with low-dose aspirin in a meta-analysis of placebo-controlled trials of vascular protection was 2.07 (95% CI: 1.61-2.66).

The absolute rate increase with aspirin above placebo was 0.12% per year (95% CI: 0.07-0.19%) with a number-needed-to-harm of 833 patients (95% CI: 526-1429). A meta-analysis of aspirin 50-1500 mg daily reported an odds ratio for any gastrointestinal bleeding of 1.68 (95% CI: 1.51-1. ... more.

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