Should All Patients With Diabetes Take Statin Drugs?

6-3 HEART PROTECTION STUDY OF CHOLESTEROL-LOWERING SIMVASTATIN IN 5963 PEOPLE WITH DIABETES Individuals with diabetes are at increased risk of cardiovascular disease (CVD) morbidity and mortality even though typically the plasma LDL-cholesterol levels of persons with diabetes are similar to the general population. Perhaps, as a consequence, most people with diabetes do not receive cholesterol-lowering drugs despite their high risk of cardiovascular events. Observational studies indicate a continuous positive relationship between CVD and LDL-cholesterol levels, without any definite threshold below which a lower concentration is not associated with lower risk.

The relationship is approximately linear when plotted on a doubling scale.1 The absolute risk of coronary mortality at each level of blood cholesterol is 3 to 5 times higher in the presence of diabetes. This study asked whether lowering LDL-cholesterol might be worthwhile among people with diabetes who do not already have ... more.

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