This has been a tricky balance for some time. The issue comes from the fact that you need to distribute your Interop assemblies with your code and you may be signing your own assemblies. If you sign your assembly then all the assemblies it references must also be signed - including the Interop assemblies.
So you have to sign them.
We use Sn. Exe to strong name our interop assemblies produced by the tools as wrappers around COM objects. We need to do this as the assemblies loading them are signed, hence they need to be signed.
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