The elisp variable system-type is what you want. So you can write (if (eq system-type 'darwin) (your-macosx-specific-configuration)).
Another possibility to consider is testing directly for the font in my . Emacs file I have the following: (let ((prefered-fonts '("-apple-espresso mono-medium-r-normal--0-0-0-0-m-0-iso10646-1"))) (dolist (font prefered-fonts) (if (and (functionp 'x-list-fonts) (x-list-fonts font)) (progn (add-to-list 'initial-frame-alist (cons 'font font)) (add-to-list 'default-frame-alist (cons 'font font)))))) this works even from console emacs in OS X, which just testing for the system wouldn't catch.
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