Twisted three-layer server-client model?

This might be something close to what you're looking for. Or at least, it could probably implement layer 2 in your scheme. The 1st and 3rd layers would just be normal ServerProtocol/ClientProtocol.

The middle has to essentially be a proxy between the two. As you can see in the example, an approach to this is attaching a clientfactory to the serverprotocol.

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