It is possible for packets exceeding the MTU (which I think is around 1500 bytes) to be discarded. For example see this . It sounds like you may be running into some form of this.
To allow it to work more reliably in different environments, it may be better to maximize the send to 1472 bytes per packet (to allow for packet overhead) and then reassemble them at the receiving end.
You are guaranteed 576 bytes (548 for UDP payload) with IPv4, but you should look to keep under 1472 bytes (1444 UDP) at least for most users.
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