Visual Studio 2010 RTM crashes on startup with “Exception has been thrown by the target of an invocation?

A colleague of mine had this issue on Win7 x64 recently. He was able to fix it by uninstalling VS 2010, uninstalling all versions of .net framework, and deleting the folders they had resided in. Then he installed VS2010 again.

He also reinstalled the VS2010 power tools as well. After doing these he was able to open VS 2010 again. Unfortunately he did all of the above before retrying VS2010, so we're not sure which of the above steps actually fixed it.

But they're worth trying before reinstalling Windows. He originally encountered the issue after he had run chkdsk in the morning. Good luck!

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