Long-term hormone replacement therapy is sometimes used in reducing cardiovascular disease (CVD) in older women at high risk (if they have hypertension, non-insulin-dependent diabetes mellitus or NIDDM, unhealthful blood cholesterol levels, are overweight, have a family history of CVD, or don't exercise). Long-term hormone replacement therapy is also useful in treating osteoporosis, because estrogen slows or prevents bone mineral loss.
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