It is recommended to use a BindingSource when multiple controls on the form use the same datasource ( Behind the Scenes: Improvements to Windows Forms Data Binding ).
Binding to a DataSource could give you benefits when dealing with a large set only a part of which gets displayed. For instance if you look at the Telerik ListView here http://www.telerik.com/help/winforms/listview-databinding.html (there are many of these component packages, this is just the latest one I am using bits and pieces from).
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