None really, since designs are available for passage over a previously placed guidewire in patients with moderate to major oesophageal dilatation. Guidewire stiffeners can also be passed into the core channel and retained there in catheters that have this channel closed at its tip (see special option available). More.
I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.