A callus is usually not dangerous or painful. If it does begin to hurt, it may be overlying a nerve, or it may be a sign of an anatomical problem. For example, people with bunions on their feet usually form deposits of dead tissue there to cushion the protruding bone at the edge of the foot near the big toe.
Hence, the callus is covering and padding the real problem. In a case like this, I advise seeing a podiatrist or an orthopedic surgeon. A dermatologist can pare down the top layers of a callus with a surgical blade, but it will return if the same action or friction on the area is repeated or if an underlying medical problem remains.
I would trust a doctor, but not a nail technician, to perform this simple procedure, and do not try it yourself since it is easy to cut too far and hit living tissue.
Doctors usually prescribe a topical, not an oral, medication. A prescription topical steroid or a topical nonsteroidal anti-inflammatory - such as tacrolimus (Protopic) or pimecrolimus (Elidel) - reduce inflammation, relieve itching, and moisturize the skin. Steroids may be safer options for treating babies and children because they are time-tested.
A patient with moderate to severe eczema must calm the rashy inflammation down and should not worry too much about using a topical steroid. Patients use it temporarily, twice daily for one to two weeks. With mild eczema - normal skin that may have an itchy, dry patch or two - a nonsteroidal anti-inflammatory should work fine and would not have steroid side effects such as thinning or atrophied skin.
(These effects happen only with long-term use of topical steroids.).
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