What Causes Progressive Supranuclear Palsy (PSP)?

We know that the symptoms of PSP are caused by a gradual deterioration of brain cells in a few tiny but important places at the base of the brain, in the region called the brainstem. One of these areas, the substantia nigra, is also affected in Parkinson's disease, and damage to this region of the brain accounts for the motor symptoms that PSP and Parkinson's have in common. Scientists do not know what causes these brain cells to degenerate.

There is no evidence that PSP is contagious, and genetic factors have not been implicated. No ethnic or racial groups have been affected more often than any others, and PSP is no more likely to occur in some geographic areas than in others. There are, however, several theories about PSP's cause.

One possibility is that an unconventional virus-like agent infects the body and takes years or decades to start producing visible effects. Creutzfeldt-Jakob disease is one disease known to be caused by such an agent. Another possibility is that random ... more.

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