Most of the drive is going to be on I-5. The driving distance is going to be 502 mi about 7 hours 45 mins and up to 10 hours 0 mins in traffic THE ROUTE: Take I-5 NORTH to I-580 to TRACY and SAN FRANCISCO at EXIT 446. Bypass downtown Los Angeles by taking I-405 NORTH towards LONG BEACH at EXIT 94A Take I-580 WEST to I-80 WEST to SAN FRANCISCO Take I-80 WEST to SAN FRANCISCO.
The fastest route is Hwy 580 east then south and pick up I-5 south. The scenic route is 101 south which then turns east at Oxnard. Allow 5-6 hours of drive time and comfort stops Distance: The direct distance between Las Vegas, Nevada and San Francisco, California is 420 miles (676 km).
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