What is the difference between UFH and LMW heparin?

Pharmaceutical preparations of unfractionated heparin (UFH) are derived from porcine or bovine tissues. These preparations contain high and low molecular weight forms, with variable anticoagulant activity. Low molecular weight (LMW) heparins are newer drugs, derived from UFH by means of controlled depolymerization.

Both UFH and LMW heparins act via antithrombin, however one feature of LMW heparin is a more predictable pharmacologic profile. LMW, in therapeutic dosages, will not prolong in vitro clotting time tests. Monitoring LMW levels requires determination of anti-Xa activity.

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