What is the drug of choice for the treatment of type 2 diabetes mellitus?

One drug choice for type 2 Diabetes Mellitus is Biguanides as you have mentioned. Examples of these are glipizide and metformin (Metaglip), metformin (Glucophage), metformin and glyburide (Glucovance), epaglinide and metormin (Parndimet), and rosiglitazone and metformin (Avandamet). The medications above with its corresponding examples of branded are called biguanides.

The action of biguanides in the treatment of type 2 DM is not clearly understood by they lower blood sugar by decreasing the amount of sugar that is produced by the liver which is the primary action of these medications. It also increase the amount of sugar absorbed by the muscle cells and decrease the body's resistance to insulin. The main advantage of using this medicines is that it does not cause hypoglycemia or weight gain in patients who use this which are common side effects of other oral hypoglycemic.. source: diabetes.webmd.com/biguanides-for-type-2....

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