Cold or allergy medicine, sedatives, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety can add to the side effects of hydrochlorothiazide and lisinopril. Tell your doctor if you regularly use any of these medicines, or any other blood pressure medications. Before taking this medication, tell your doctor if you are using any of the following drugs: other diuretics (water pills) or blood pressure medications gold injections to treat arthritis lithium (Lithobid, Eskalith) cholestyramine (Prevalite, Questran) or colestipol (Colestid) steroids (prednisone and others) NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), indomethacin, naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others; or insulin or diabetes medicine taken by mouth This list is not complete and there may be other drugs that can interact with hydrochlorothiazide and lisinopril.
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