What role does CD8 play in MS?

A. In MS, myelin (the protective coating around the nerve) is damaged by genetic or environmental factors. As the myelin becomes injured this triggers an immune reaction from T cells.

We found that CD8 was really critical in injuring axons, which are responsible for carrying electrical impulses from the nerve. That was a really novel finding to the point where we received a patent for that observation and now Mayo owns the patent for the rights of any treatment that involves the use of deleting CD8 as an approach to MS or any other viral or autoimmune disease. When we discovered this no one was talking about CD8 in MS.

However, now CD8 has since become the buzz word in MS. There are no drugs that specifically target CD8, but I am convinced that this is the cell that finally induces the long term injury in MS. Q.

What are you working on right now? A. Reparative antibodies.

I had this idea that antibodies could be both damaging and reparative. The idea was that if antibodies were ... more.

I cant really gove you an answer,but what I can give you is a way to a solution, that is you have to find the anglde that you relate to or peaks your interest. A good paper is one that people get drawn into because it reaches them ln some way.As for me WW11 to me, I think of the holocaust and the effect it had on the survivors, their families and those who stood by and did nothing until it was too late.