Stage 4 sleep is the phase of sleep called deep sleep. It is also called non-rapid eye movement (nREM) sleep. Most patients with irritable bowel syndrome (IBS) and other functional syndromes, such as fibromyalgia, have abnormalities of Stage 4 sleep that contribute to awakening in the morning feeling tired and unrefreshed.
Another phase of sleep is called rapid eye movement sleep (REM), which is associated with dreaming, arousal, altered activity of the autonomic nervous system and altered colon function. Increased REM sleep occurs in some patients with IBS and other functional syndromes.
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