Over-the-counter antacids are usually safe and effective when taken occasionally to relieve heartburn, but some important distinctions need to be made:Be careful not to abuse antacids. Regular use can lead to such side effects as malabsorption of nutrients, bowel irregularities, and kidney stones. Furthermore, although antacids often provide immediate relief, they can produce what is known as acid rebound three or four hours after use.
This means that the body will try to overcompensate for the neutralization of gastric acid by secreting even more acid. While this may not be a problem in treating indigestion, it may play a role in delaying the healing of ulcers. Limit the use of sodium bicarbonate.
Many people take sodium bicarbonate (baking soda) for relief of acid indigestion. (Alka-Seltzer is simply ordinary baking soda in a fizzy form.) Although sodium bicarbonate can be useful in the short term, using it often or regularly can increase your sodium intake to unnecessarily high levels. Long-term administration can cause systemic alkalosis (excessively high pH levels throughout the body), leading to such complications as the formation of kidney stones, nausea, vomiting, headache, and mental confusion.
Avoid antacids that contain aluminum. These products (such as Maalox, Rolaids, Digel, Mylanta, and Riopan) have issues of long-term safety due to the aluminum in them. Aluminum may play a role in impairing mental function as well as in diseases of the nervous system including Alzheimer's disease, Parkinson's disease, and Lou Gehrig's disease (amyotrophic lateral sclerosis).
Absorption of aluminum is made worse if a meal contains any source of citric acid, such as citrus fruit, juice, or soda pop. In my opinion, there is no reason to use aluminum-containing antacids, because the potential risks far outweigh the short-term benefit. Follow dosage instructions.
It is especially important to avoid taking too much of a magnesium salt such as magnesium oxide, hydroxide, or carbonate. Besides acting as a mild antacid, magnesium salts can exert a laxative effect making diarrhea a definite risk.
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