What were some difficulties Rome's enemies would have reaching rome?

Rome does not have impressive geographic defences. It is not built on top of a sheer cliff, or an island. It is built on seven hills, which provide some high places for defence.

This is less important in modern Rome This question seems to indicate that the Rome in question is Ancient Rome. During this period, Rome's greatest defence was her legions and commanders. However, the city also had formidable wall systems which prevented an imposing obstacle.

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