In addition to Bangkok, where there is hard evidence that IDU can be enrolled and retained, there are several other IDU cohorts which could participate in future trials. Also in Thailand, a cohort in Chiang Mai supported by the National Institute of Drug Abuse (NIDA, the NIH institute focused primarily on substance abuse), led by David Celentano and Vinai Suriyanon, found a high, steady seroincidence among 400 IDU of 7.7/100PY (95% confidence interval 5.0-10.4) despite risk reduction counseling, condom promotion, and training in safe injection practices. Virtually all newly infected IDU in this cohort have the same HIV subtype E found in cohorts at sexual risk in Chiang Mai.
Several sites are now being built up in China. The HVTN is supporting a site in Guangxi Province (southern China) together with the HIV Prevention Trials Network (HPTN), which also works in Xinjiang, in China's far northwest. Both sites are involved in HPTN 039, a cohort development study aimed at assessing ... more.
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